The Huanan seafood wholesale market in Wuhan was the early epicenter of the COVID-19 pandemic (2024)

Worobey, M., Levy, J. I., Malpica Serrano, L., Crits-Christoph, A., Pekar, J. E., Goldstein, S. A., Rasmussen, A. L., Kraemer, M. U. G., Newman, C., Koopmans, M. P. G., Suchard, M. A., Wertheim, J. O., Lemey, P., Robertson, D. L., Garry, R. F., Holmes, E. C., Rambaut, A., & Andersen, K. G. (2022). The Huanan seafood wholesale market in Wuhan was the early epicenter of the COVID-19 pandemic. Science, 377(6609), 951-959. https://doi.org/10.1126/science.abp8715

Worobey, Michael ; Levy, Joshua I. ; Malpica Serrano, Lorena et al. / The Huanan seafood wholesale market in Wuhan was the early epicenter of the COVID-19 pandemic. In: Science. 2022 ; Vol. 377, No. 6609. pp. 951-959.

@article{88c7a9c370dc404d893639f35d803875,

title = "The Huanan seafood wholesale market in Wuhan was the early epicenter of the COVID-19 pandemic",

abstract = "Understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019 is critical to preventing future zoonotic outbreaks before they become the next pandemic. The Huanan Seafood Wholesale Market in Wuhan, China, was identified as a likely source of cases in early reports, but later this conclusion became controversial. We show here that the earliest known COVID-19 cases from December 2019, including those without reported direct links, were geographically centered on this market. We report that live SARS-CoV-2–susceptible mammals were sold at the market in late 2019 and that within the market, SARS-CoV-2–positive environmental samples were spatially associated with vendors selling live mammals. Although there is insufficient evidence to define upstream events, and exact circ*mstances remain obscure, our analyses indicate that the emergence of SARS-CoV-2 occurred through the live wildlife trade in China and show that the Huanan market was the epicenter of the COVID-19 pandemic.",

author = "Michael Worobey and Levy, {Joshua I.} and {Malpica Serrano}, Lorena and Alexander Crits-Christoph and Pekar, {Jonathan E.} and Goldstein, {Stephen A.} and Rasmussen, {Angela L.} and Kraemer, {Moritz U. G.} and Chris Newman and Koopmans, {Marion P. G.} and Suchard, {Marc A.} and Wertheim, {Joel O.} and Philippe Lemey and Robertson, {David L.} and Garry, {Robert F.} and Holmes, {Edward C.} and Andrew Rambaut and Andersen, {Kristian G.}",

note = "Publisher Copyright: {\textcopyright} 2022 American Association for the Advancement of Science. All rights reserved.",

year = "2022",

month = aug,

day = "26",

doi = "10.1126/science.abp8715",

language = "English",

volume = "377",

pages = "951--959",

journal = "Science",

issn = "0036-8075",

publisher = "AMER ASSOC ADVANCEMENT SCIENCE",

number = "6609",

}

Worobey, M, Levy, JI, Malpica Serrano, L, Crits-Christoph, A, Pekar, JE, Goldstein, SA, Rasmussen, AL, Kraemer, MUG, Newman, C, Koopmans, MPG, Suchard, MA, Wertheim, JO, Lemey, P, Robertson, DL, Garry, RF, Holmes, EC, Rambaut, A & Andersen, KG 2022, 'The Huanan seafood wholesale market in Wuhan was the early epicenter of the COVID-19 pandemic', Science, vol. 377, no. 6609, pp. 951-959. https://doi.org/10.1126/science.abp8715

The Huanan seafood wholesale market in Wuhan was the early epicenter of the COVID-19 pandemic. / Worobey, Michael; Levy, Joshua I.; Malpica Serrano, Lorena et al.
In: Science, Vol. 377, No. 6609, 26.08.2022, p. 951-959.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The Huanan seafood wholesale market in Wuhan was the early epicenter of the COVID-19 pandemic

AU - Worobey, Michael

AU - Levy, Joshua I.

AU - Malpica Serrano, Lorena

AU - Crits-Christoph, Alexander

AU - Pekar, Jonathan E.

AU - Goldstein, Stephen A.

AU - Rasmussen, Angela L.

AU - Kraemer, Moritz U. G.

AU - Newman, Chris

AU - Koopmans, Marion P. G.

AU - Suchard, Marc A.

AU - Wertheim, Joel O.

AU - Lemey, Philippe

AU - Robertson, David L.

AU - Garry, Robert F.

AU - Holmes, Edward C.

AU - Rambaut, Andrew

AU - Andersen, Kristian G.

N1 - Publisher Copyright:© 2022 American Association for the Advancement of Science. All rights reserved.

PY - 2022/8/26

Y1 - 2022/8/26

N2 - Understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019 is critical to preventing future zoonotic outbreaks before they become the next pandemic. The Huanan Seafood Wholesale Market in Wuhan, China, was identified as a likely source of cases in early reports, but later this conclusion became controversial. We show here that the earliest known COVID-19 cases from December 2019, including those without reported direct links, were geographically centered on this market. We report that live SARS-CoV-2–susceptible mammals were sold at the market in late 2019 and that within the market, SARS-CoV-2–positive environmental samples were spatially associated with vendors selling live mammals. Although there is insufficient evidence to define upstream events, and exact circ*mstances remain obscure, our analyses indicate that the emergence of SARS-CoV-2 occurred through the live wildlife trade in China and show that the Huanan market was the epicenter of the COVID-19 pandemic.

AB - Understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019 is critical to preventing future zoonotic outbreaks before they become the next pandemic. The Huanan Seafood Wholesale Market in Wuhan, China, was identified as a likely source of cases in early reports, but later this conclusion became controversial. We show here that the earliest known COVID-19 cases from December 2019, including those without reported direct links, were geographically centered on this market. We report that live SARS-CoV-2–susceptible mammals were sold at the market in late 2019 and that within the market, SARS-CoV-2–positive environmental samples were spatially associated with vendors selling live mammals. Although there is insufficient evidence to define upstream events, and exact circ*mstances remain obscure, our analyses indicate that the emergence of SARS-CoV-2 occurred through the live wildlife trade in China and show that the Huanan market was the epicenter of the COVID-19 pandemic.

U2 - 10.1126/science.abp8715

DO - 10.1126/science.abp8715

M3 - Article

SN - 0036-8075

VL - 377

SP - 951

EP - 959

JO - Science

JF - Science

IS - 6609

ER -

Worobey M, Levy JI, Malpica Serrano L, Crits-Christoph A, Pekar JE, Goldstein SA et al. The Huanan seafood wholesale market in Wuhan was the early epicenter of the COVID-19 pandemic. Science. 2022 Aug 26;377(6609):951-959. Epub 2022 Jul 26. doi: 10.1126/science.abp8715